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Thus, loss of mitochondrial complex III, or the downstream mitochondrial complex IV, diminishes DHODH activity, limiting de novo pyrimidine synthesis

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Although the exact metabolites responsible are not detailed in the study, these effects are typically attributed to saponins and triterpenoids present in the leaves (Pitchakarn et al

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It was also noted that the promoter region of the GSTA3 gene contains three putative binding sites for steroidogenic factor 1 (SF-1), which serves as a master regulator of endocrine functions